Keratin-15 high expression links with lymph node metastasis and poor survival prognosis in epithelial ovarian cancer patients.

ABSTRACT:

Background

Keratin-15 (KRT15) involves in the progression and owns prognostic values in several solid cancers, whose clinical role in epithelial ovarian cancer (EOC) is rarely reported. This study aimed to identify the association of KRT15 expression with tumor features and survival of surgical EOC patients.

Methods

Formalin-fixed paraffin-embedded tumor tissues of 140 EOC patients who underwent tumor resection were retrieved for KRT15 determination using immunohistochemistry (IHC) assay.

Results

The median (interquartile range) KRT15 IHC score was 0.0 (0.0-1.0), ranging from 0.0 to 12.0. Among all, 36.4% of patients had positive KRT15 expression (IHC score > 0) and 15.0% of patients had high KRT15 expression (IHC score > 3). KRT15 was positively related to lymph node

SUBMITTER: Feng X 

PROVIDER: S-EPMC11473747 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature