Chronic stress in adulthood results in microvascular dysfunction and subsequent depressive-like behavior.

ABSTRACT: Depression is a prevalent mental disorder characterized by unknown pathogenesis and challenging treatment. Recent meta-analyses reveal an association between cardiovascular risk factors and an elevated risk of depression. Despite this, the precise role of vascular injury in depression development remains unclear. In this investigation, we assess vascular system function in three established animal models of depression- chronic unpredictable mild stress (CUMS), chronic social defeat stress (CSDS) and maternal separation (MS)-utilizing ultrasonography and laser Doppler measurement. All three model animals exhibit anhedonia and despair-like behavior. However, significant microvascular dysfunction (not macrovascular) is observed in animals subjected to CUMS and CSDS models, while such dysfunct

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11473760 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature