Pre- and postsynaptic signatures in the prelimbic cortex associated with "alcohol use disorder" in the rat.

ABSTRACT: The transition to alcohol use disorder (AUD) involves persistent neuroadaptations in executive control functions primarily regulated by the medial prefrontal cortex. However, the neurophysiological correlates to behavioral manifestations of AUD are not fully defined. The association between cortical neuroadaptations and behavioral manifestations of addiction was studied using a multi-symptomatic operant model based on the DSM-5 diagnostic criteria for AUD. This model aimed to characterize an AUD-vulnerable and AUD-resistant subpopulation of outbred male Wistar rats and was combined with electrophysiological measurements in the prelimbic cortex (PL). Mirroring clinical observations, rats exhibited individual variability in their vulnerability to develop AUD-like behavior, including motivati

SUBMITTER: Domi A 

PROVIDER: S-EPMC11473806 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature