GRHL2 regulates keratinocyte EMT-MET dynamics and scar formation during cutaneous wound healing.

ABSTRACT: After cutaneous wounds successfully heal, keratinocytes that underwent the epithelial-mesenchymal transition (EMT) regain their epithelial characteristics, while in scar tissue, epidermal cells persist in a mesenchymal state. However, the regulatory mechanisms governing this reversion are poorly understood, and the impact of persistent mesenchymal-like epidermal cells in scar tissue remains unclear. In the present study, we found that during wound healing, the regulatory factor GRHL2 is highly expressed in normal epidermal cells, downregulated in EMT epidermal cells, and upregulated again during the process of mesenchymal-epithelial transition (MET). We further demonstrated that interfering with GRHL2 expression in epidermal cells can effectively induce the EMT. Conversely, the overexpress

SUBMITTER: Chen T 

PROVIDER: S-EPMC11473813 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature