Testing of rapid evaporative mass spectrometry for histological tissue classification and molecular diagnostics in a multi-site study.

ABSTRACT:

Background

While REIMS technology has successfully been demonstrated for the histological identification of ex-vivo breast tumor tissues, questions regarding the robustness of the approach and the possibility of tumor molecular diagnostics still remain unanswered. In the current study, we set out to determine whether it is possible to acquire cross-comparable REIMS datasets at multiple sites for the identification of breast tumors and subtypes.

Methods

A consortium of four sites with three of them having access to fresh surgical tissue samples performed tissue analysis using identical REIMS setups and protocols. Overall, 21 breast cancer specimens containing pathology-validated tumor and adipose tissues were analyzed and results were compared using uni- and multivariate stat

SUBMITTER: Kaufmann M 

PROVIDER: S-EPMC11473823 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature