Fertility protection during chemotherapy treatment by boosting the NAD(P)⁺ metabolome.

ABSTRACT: Chemotherapy induced ovarian failure and infertility is an important concern in female cancer patients of reproductive age or younger, and non-invasive, pharmacological approaches to maintain ovarian function are urgently needed. Given the role of reduced nicotinamide adenine dinucleotide phosphate (NADPH) as an essential cofactor for drug detoxification, we sought to test whether boosting the NAD(P)⁺ metabolome could protect ovarian function. We show that pharmacological or transgenic strategies to replenish the NAD⁺ metabolome ameliorates chemotherapy induced female infertility in mice, as measured by oocyte yield, follicle health, and functional breeding trials. Importantly, treatment of a triple-negative breast cancer mouse model with the NAD⁺ precursor

SUBMITTER: Ho WJ 

PROVIDER: S-EPMC11473878 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature