Temporal maturation of Sertoli cells during the establishment of the cycle of the seminiferous epithelium†.

ABSTRACT: Sertoli cells, omnipresent, somatic cells within the seminiferous tubules of the mammalian testis are essential to male fertility. Sertoli cells maintain the integrity of the testicular microenvironment, regulate hormone synthesis, and of particular importance, synthesize the active derivative of vitamin A, all trans retinoic acid (atRA), which is required for germ cell differentiation and the commitment of male germ cells to meiosis. Stages VIII-IX, when atRA synthesis occurs in the testis, coincide with multiple germ cell development and testicular restructuring events that rely on Sertoli cell gene products to proceed normally. In this study, we have synchronized and captured the mouse testis at four recurrent points of atRA synthesis to observe transcriptomic changes within Sertoli cel

SUBMITTER: Havel SL 

PROVIDER: S-EPMC11473899 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature