Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice.

ABSTRACT: Mouse behavioral genetic mapping studies can identify genomic intervals modulating complex traits under well-controlled environmental conditions and have been used to study ethanol behaviors to aid in understanding genetic risk and the neurobiology of alcohol use disorder (AUD). However, historically such studies have produced large confidence intervals, thus complicating identification of potential causal candidate genes. Diversity Outbred (DO) mice offer the ability to perform high-resolution quantitative trait loci (QTL) mapping on a very genetically diverse background, thus facilitating identification of candidate genes. Here, we studied a population of 636 male DO mice with four weeks of intermittent ethanol access via a three-bottle choice procedure, producing a progressive ethanol c

SUBMITTER: Mignogna KM 

PROVIDER: S-EPMC11473901 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature