Coupling of cell growth modulation to asymmetric division and cell cycle regulation in <i>Caulobacter crescentus</i>.

ABSTRACT: In proliferating bacteria, growth rate is often assumed to be similar between daughter cells. However, most of our knowledge of cell growth derives from studies on symmetrically dividing bacteria. In many α-proteobacteria, asymmetric division is a normal part of the life cycle, with each division producing daughter cells with different sizes and fates. Here, we demonstrate that the functionally distinct swarmer and stalked daughter cells produced by the model α-proteobacterium Caulobacter crescentus can have different average growth rates under nutrient-replete conditions despite sharing an identical genome and environment. The discrepancy in growth rate is due to a growth slowdown associated with the cell cycle stage preceding DNA replication (the G1 phase), which initiates in the

SUBMITTER: Glenn S 

PROVIDER: S-EPMC11474046 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature