The Drosophila tracheal terminal cell as a model for branching morphogenesis.

ABSTRACT: The terminal cells of the Drosophila larval tracheal system are perhaps the simplest delivery networks, providing an analogue for mammalian vascular growth and function in a system with many fewer components. These cells are a prime example of single-cell morphogenesis, branching significantly over time to adapt to the needs of the growing tissue they supply. While the genetic mechanisms governing local branching decisions have been studied extensively, an understanding of the emergence of a global network architecture is still lacking. Mapping out the full network architecture of populations of terminal cells at different developmental times of Drosophila larvae, we find that cell growth follows scaling laws relating the total edge length, supply area, and branch density. Us

SUBMITTER: Gavrilchenko T 

PROVIDER: S-EPMC11474054 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature