Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function.

ABSTRACT: Systems consolidation is a common feature of learning and memory systems, in which a long-term memory initially stored in one brain region becomes persistently stored in another region. We studied the dynamics of systems consolidation in simple circuit architectures with two sites of plasticity, one in an early-learning and one in a late-learning brain area. We show that the synaptic dynamics of the circuit during consolidation of an analog memory can be understood as a temporal integration process, by which transient changes in activity driven by plasticity in the early-learning area are accumulated into persistent synaptic changes at the late-learning site. This simple principle naturally leads to a speed-accuracy tradeoff in systems consolidation and provides insight into how the circui

SUBMITTER: Bhasin BJ 

PROVIDER: S-EPMC11474072 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature