YkuR functions as a protein deacetylase in <i>Streptococcus mutans</i>.

ABSTRACT: Protein acetylation is a common and reversible posttranslational modification tightly governed by protein acetyltransferases and deacetylases crucial for various biological processes in both eukaryotes and prokaryotes. Although recent studies have characterized many acetyltransferases in diverse bacterial species, only a few protein deacetylases have been identified in prokaryotes, perhaps in part due to their limited sequence homology. In this study, we identified YkuR, encoded by smu_318, as a unique protein deacetylase in Streptococcus mutans. Through protein acetylome analysis, we demonstrated that the deletion of ykuR significantly upregulated protein acetylation levels, affecting key enzymes in translation processes and metabolic pathways, including starch and su

SUBMITTER: Ma Q 

PROVIDER: S-EPMC11474102 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature