Integrative Multiomic Profiling of Triple-Negative Breast Cancer for Identifying Suitable Therapies.

ABSTRACT:

Purpose

Triple-negative breast cancer (TNBC) is a heterogeneous disease that carries the poorest prognosis of all breast cancers. Although novel TNBC therapies in development are frequently targeted toward tumors carrying a specific genomic, transcriptomic, or protein biomarker, it is poorly understood how these biomarkers are correlated.

Experimental design

To better understand the molecular features of TNBC and their correlation with one another, we performed multimodal profiling on a cohort of 95 TNBC. Our approach involved quantifying tumor-infiltrating lymphocytes through hematoxylin and eosin staining, assessing the abundance of retinoblastoma, androgen receptor, and PDL1 proteins through IHC, and carrying out transcriptomic profiling using the NanoString BC360 platfor

SUBMITTER: Jovanovic B 

PROVIDER: S-EPMC11474168 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature