Reduced brain connectivity underlying value-based choices and outcomes in stimulant use disorder.

ABSTRACT:

Background

Patients with stimulant use disorder (SUD) show impairments when making value-based choices that are associated with disruptions in neural processing across brain networks. Making optimal choices requires learning from outcomes to update knowledge and further optimise ongoing behaviour. The optimal functioning of neural systems that underpin the ability to make favourable choices is an essential component for life functioning, and successful recovery in patients with SUD. Therefore, we sought to investigate the neural processes that underpin value-based choices in SUD patients. We hypothesise that patients with SUD have reduced functional connectivity while making financial choices during a probabilistic reinforcement learning task.

Methods

We investigated connect

SUBMITTER: Nestor LJ 

PROVIDER: S-EPMC11474215 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature