Intensity Modulated Carbon Ion Radiation Therapy Using Pencil Beam Scanning Technology for Patients With Unresectable Sacrococcygeal Chordoma.

ABSTRACT:

Purpose

To investigate the safety and efficacy of intensity modulated carbon ion radiation therapy (IM-CIRT) using pencil beam scanning technology for patients with unresectable sacrococcygeal chordoma (SC).

Methods and materials

A total of 35 patients with unresectable SC were retrospectively analyzed, including 54.3% (19/35) recurrent cases. In 68.6% (24/35) cases, tumor was located in S2 or above, and all cases were treated with hypofractionated IM-CIRT. The median dose was 70.4 Gy (range, 69-80 Gy) (relative biologic effectiveness) in 16 fractions (range, 16-23 fractions), typically delivered over 5 fractions per week.

Results

The 3-year overall survival, cause-specific survival, progression-free survival, locoregional progression-free survival, and distant metast

SUBMITTER: Bao C 

PROVIDER: S-EPMC11474278 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature