Recommendations for the analysis of rodent gait data to evaluate osteoarthritis treatments.

ABSTRACT: Behavioral assays of animal pain and disability can increase the clinical relevance of a preclinical study. However, pain and symptoms are difficult to measure in preclinical models. Because animals often alter their movement patterns to reduce or avoid joint pain, gait analysis can be an important tool for quantifying OA-related symptoms in rodents. Technologies to measure rodent gait continue to advance and have been the focus of prior reviews. Regardless of the techniques used, the analysis of rodent gait data can be complex due to multiple confounding variables. The goal of this review is to discuss recent advances in the understanding of OA-related gait changes and provide recommendations on the analysis of gait data. Recent studies suggest OA-affected animals reduce vertical loading

SUBMITTER: Chan KM 

PROVIDER: S-EPMC11474404 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature