Intense simplified strategy for newly diagnosed type 2 diabetes in patients with severe hyperglycaemia: multicentre, open label, randomised trial.

ABSTRACT:

Objective

To evaluate whether the intense simplified strategy, which comprises short term intensive insulin therapy (SIIT) followed by subsequent oral antihyperglycaemic regimens, could improve long term glycaemic outcomes in patients with newly diagnosed type 2 diabetes mellitus and severe hyperglycaemia.

Design

Multicentre, open label, randomised trial.

Setting

15 hospitals in China between December 2017 and December 2020.

Participants

412 patients with newly diagnosed type 2 diabetes and significant hyperglycaemia (HbA_1c ≥8.5%).

Interventions

All randomised participants initially received SIIT for 2-3 weeks, followed by linagliptin 5 mg/day, metformin 1000 mg/day, combination linagliptin plus metformin, or lifestyle modification alone (cont

SUBMITTER: Liu L 

PROVIDER: S-EPMC11474422 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature