Vitamin D serum concentration is prospectively associated with depressive symptoms in the EpiFloripa Aging Cohort Study: a structural equation modeling approach.

ABSTRACT:

Objective

To evaluate the direct, indirect, and total prospective effects of serum concentrations of 25-hydroxycholecalciferol (25[OH]D) on depressive symptoms in older adults.

Methods

Data from the second (2013-2015) and third (2017-2019) waves of the EpiFloripa Aging Cohort Study (= 60 years) were analyzed. Depressive symptoms were assessed with the 15-item Geriatric Depression Scale. 25(OH)D levels were measured using the microparticle chemiluminescence method. A directed acyclic graph was constructed to identify the minimum set of adjustments. Structural equation modeling analysis was used to determine the effects of 25(OH)D on depressive symptoms.

Results

Data from 574 older adults (63.1% female) were analyzed. In the follow-up (n=390), 16.2% of them presented se

SUBMITTER: Ceolin G 

PROVIDER: S-EPMC11474441 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature