Dementia risk reduction between DOACs and VKAs in AF: A systematic review and meta-analysis.

ABSTRACT:

Introduction

Direct oral anticoagulants (DOACs) become the recommended treatment over vitamin K antagonists (VKA) in patients with non-valvular atrial fibrillation (AF). However, their effectiveness in reducing cognitive impairment and dementia compared to VKA remains unclear.

Methods

A systematic literature search was conducted on Ovid MEDLINE, EMBASE, and Cochrane Database. Randomized controlled trials, cohort, or case-control study that assessed incident dementia between AF patients who received DOAC compared to VKA were selected. Relevant study characteristics and the number of incident dementia diagnosis or hazard ratios (HRs) for incident dementia and each dementia subtypes were extracted. Random-effects model was used to perform meta-analysis. Standardized mean differ

SUBMITTER: Chokesuwattanaskul A 

PROVIDER: S-EPMC11474537 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature