Increased interleukin-6 levels are associated with atrioventricular conduction delay in severe COVID-19 patients.

ABSTRACT:

Background

Severely ill patients with coronavirus disease 2019 (COVID-19) show an increased risk of new-onset atrioventricular blocks (AVBs), associated with high rates of short-term mortality. Recent data suggest that the uncontrolled inflammatory activation observed in these patients, specifically interleukin (IL)-6 elevation, may play an important pathogenic role by directly affecting cardiac electrophysiology. The aim of our study was to assess the acute impact of IL-6 changes on electrocardiographic indices of atrioventricular conduction in severe COVID-19.

Methods

We investigated (1) the behavior of PR-interval and PR-segment in patients with severe COVID-19 during active phase and recovery, and (2) their association with circulating IL-6 levels over time.

Results</

SUBMITTER: Accioli R 

PROVIDER: S-EPMC11474750 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature