Correlation of the treatment sensitivity of patient-derived organoids with treatment outcomes in patients with head and neck cancer (SOTO): protocol for a prospective observational study.

ABSTRACT:

Introduction

Organoids have been successfully used in several areas of cancer research and large living biobanks of patient-derived organoids (PDOs) have been developed from various malignancies. The characteristics of the original tumour tissue such as mutation signatures, phenotype and genetic diversity are well preserved in organoids, thus showing promising results for the use of this model in translational research. In this study, we aim to assess whether we can generate PDOs from head and neck squamous cell carcinoma (HNSCC) samples and whether PDOs can be used to predict treatment sensitivity in HNSCC patients as well as to explore potential biomarkers.

Methods and analysis

This is a prospective observational study at a single centre (Guy's and St Thomas' NHS Foundatio

SUBMITTER: Vasiliadou I 

PROVIDER: S-EPMC11474813 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature