Seasonal Changes in the Oxidative Potential of Urban Air Pollutants: The Influence of Emission Sources and Proton- and Ligand-Mediated Dissolution of Transition Metals.

ABSTRACT: The inhalation of fine particulate matter (PM_2.5) is a major contributor to adverse health effects from air pollution worldwide. An important toxicity pathway is thought to follow oxidative stress from the formation of exogenous reactive oxygen species (ROS) in the body, a proxy of which is oxidative potential (OP). As redox-active transition metals and organic species are important drivers of OP in urban environments, we investigate how seasonal changes in emission sources, aerosol chemical composition, acidity, and metal dissolution influence OP dynamics. Using a kinetic model of the lung redox chemistry, we predicted ROS (O₂ ^•-, H₂O₂, ^•OH) formation with input parameters comprising the ambient concentrations of PM_2.5

SUBMITTER: Shahpoury P 

PROVIDER: S-EPMC11474821 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature