GLS2 reduces the occurrence of epilepsy by affecting mitophagy function in mouse hippocampal neurons.

ABSTRACT:

Background

Altered mitophagy has been observed in various neurological disorders, such as epilepsy. The role of mitophagy in causing neuronal damage during epileptic episodes is significant, and recent research has indicated that GLS2 plays a crucial role in regulating autophagy. However, exactly how GLS2 affects epilepsy is still unclear.

Aims

To investigate the expression and distribution characteristics of GLS2 in epilepsy, and then observed the changes in behavior and electrophysiology caused by overexpression of GLS2 in epileptic mice, and determined whether GLS2 regulated seizure-like changes in the mouse model through the protective mechanism of mitophagy.

Results

The expression of GLS2 in a kainic acid (KA)-induced epileptic mouse model and aglutamate-inducedn

SUBMITTER: Gao Y 

PROVIDER: S-EPMC11474837 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature