Cancer-associated foam cells hamper protective T cell immunity and favor tumor progression in human colon carcinogenesis.

ABSTRACT:

Background

Colorectal cancer (CRC) remains a significant healthcare burden worldwide, characterized by a complex interplay between obesity and chronic inflammation. While the relationship between CRC, obesity and altered lipid metabolism is not fully understood, there are evidences suggesting a link between them. In this study, we hypothesized that dysregulated lipid metabolism contributes to local accumulation of foam cells (FC) in CRC, which in turn disrupts antitumor immunosurveillance.

Methods

Tumor infiltrating FC and CD8⁺ were quantified by digital pathology in patients affected by T2-T4 CRC with any N stage undergoing radical upfront surgery (n=65) and correlated with patients' clinical outcomes. Multiparametric high-resolution flow cytometry analysis and b

SUBMITTER: Daveri E 

PROVIDER: S-EPMC11474856 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature