Metronomic chemotherapy for paediatric extracranial solid tumours: a systematic review and meta-analysis of randomised clinical trials.

ABSTRACT:

Background

Metronomic chemotherapy ('less is more, regularly') could be an alternative to the maximum tolerated dose ('the more, the better') in the chemotherapeutic cancer treatment of high-risk malignant solid extracranial tumours in children or young adults.

Objective

To evaluate the efficacy of metronomic chemotherapy compared with placebo or stop treatment in paediatric patients with extracranial malignant solid tumours.

Methods

We searched the databases MEDLINE and CENTRAL on 8 September 2023 and included randomised clinical trials (RCTs). Primary outcome was overall survival, and the main outcome measure was the HR.

Results

We identified three RCTs with parallel assignment and intention-to-treat analyses of data from 775 people. The studies primarily rep

SUBMITTER: Peinemann F 

PROVIDER: S-EPMC11474900 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature