Repositioning Brusatol as a Transmission Blocker of Malaria Parasites.

ABSTRACT: Currently, primaquine is the only malaria transmission-blocking drug recommended by the WHO. Recent efforts have highlighted the importance of discovering new agents that regulate malarial transmission, with particular interest in agents that can be administered in a single low dose, ideally with a discrete and Plasmodium-selective mechanism of action. Here, our team demonstrates an approach to identify malaria transmission-blocking agents through a combination of in vitro screening and in vivo analyses. Using a panel of natural products, our approach identified potent transmission blockers, as illustrated by the discovery of the transmission-blocking efficacy of brusatol. As a member of a large family of biologically active natural products, this discovery provides a

SUBMITTER: Cox A 

PROVIDER: S-EPMC11474950 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature