Novel H-2D^b-restricted CD8 epitope derived from mouse MAGE-type antigen P1A mediates antitumor immunity in C57BL/6 mice.

ABSTRACT:

Background

Melanoma antigen gene (MAGE)-type antigens are promising targets for cancer immunotherapy as they are expressed in cancer cells but not in normal tissues, except for male germline cells. The mouse P1A antigen shares this MAGE-type expression pattern and has been used as a target antigen in preclinical tumor models aiming to induce antitumor CD8⁺ T-cell responses. However, so far only one MHC I-restricted P1A epitope has been identified. It is presented by H-2L^d in mice of the H-2^d genetic background such as DBA/2 and BALB/c. Given the availability of multiple genetically altered strains of mice in the C57BL/6 background, it would be useful to define P1A T-cell epitopes presented by the H-2^b haplotype, to facilitate more refined

SUBMITTER: McAuliffe J 

PROVIDER: S-EPMC11474967 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature