8-Hydroxyquinoline Series Exerts Bactericidal Activity against <i>Mycobacterium tuberculosis</i> Via Copper-Mediated Toxicity.

ABSTRACT: New drugs and mechanisms of action targeting Mycobacterium tuberculosis are urgently needed to solve the global pandemic of tuberculosis. We previously demonstrated that the 8-hydroxyquinoline series has rapid bactericidal activity against M. tuberculosis. In this work, we determined that the activity of the 8HQ series is potentiated by copper ions and that the activity is dependent on copper since activity was reduced when copper was depleted from the medium. We determined that exposure to 8HQs led to an increase in intracellular copper. The increase in copper ions was specific since we saw no changes for other metal cations (zinc, iron, magnesium, manganese, or calcium). We observed the transient generation of reactive oxygen species after 8HQ exposure which disappeared by

SUBMITTER: Bhagwat A 

PROVIDER: S-EPMC11474974 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature