Inter-subject stability and regional concentration estimates of 3D-FID-MRSI in the human brain at 7 T.

ABSTRACT:

Purpose

Recently, a 3D-concentric ring trajectory (CRT)-based free induction decay (FID)-MRSI sequence was introduced for fast high-resolution metabolic imaging at 7 T. This technique provides metabolic ratio maps of almost the entire brain within clinically feasible scan times, but its robustness has not yet been thoroughly investigated. Therefore, we have assessed quantitative concentration estimates and their variability in healthy volunteers using this approach.

Methods

We acquired whole-brain 3D-CRT-FID-MRSI at 7 T in 15 min with 3.4 mm nominal isometric resolution in 24 volunteers (12 male, 12 female, mean age 27 ± 6 years). Concentration estimate maps were calculated for 15 metabolites using internal water referencing and evaluated in 55 different regions of interest

SUBMITTER: Hangel G 

PROVIDER: S-EPMC11475238 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature