De Novo Designed Peptide and Protein Hairpins Self-Assemble into Sheets and Nanoparticles.

ABSTRACT: The design and assembly of peptide-based materials has advanced considerably, leading to a variety of fibrous, sheet, and nanoparticle structures. A remaining challenge is to account for and control different possible supramolecular outcomes accessible to the same or similar peptide building blocks. Here a de novo peptide system is presented that forms nanoparticles or sheets depending on the strategic placement of a "disulfide pin" between two elements of secondary structure that drive self-assembly. Specifically, homodimerizing and homotrimerizing de novo coiled-coil α-helices are joined with a flexible linker to generate a series of linear peptides. The helices are pinned back-to-back, constraining them as hairpins by a disulfide bond placed either proximal or distal to the linker. Comp

SUBMITTER: Galloway JM 

PROVIDER: S-EPMC11475375 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature