Alzheimer's disease pathology is associated with earlier alterations to blood-brain barrier water permeability compared with healthy ageing in TgF344-AD rats.

ABSTRACT: The effects of Alzheimer's disease (AD) and ageing on blood-brain barrier (BBB) breakdown are investigated in TgF344-AD and wild-type rats aged 13, 18 and 21 months. Permeability surface area products of the BBB to water (PS_w ) and gadolinium-based contrast agent (PS_g ) were measured in grey matter using multiflip angle multiecho dynamic contrast-enhanced MRI. At 13 months of age, there was no significant difference in PS_w between TgF344-AD and wild-types (p = 0.82). Between 13 and 18 months, PS_w increased in TgF344-AD rats (p = 0.027), but not in wild-types (p = 0.99), leading to significantly higher PS_w in TgF344-AD rats at 18 months, as previously reported (p = 0.012). Between 18 and 21 months, PS_w values increased in wil

SUBMITTER: Dickie BR 

PROVIDER: S-EPMC11475392 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature