Designing Covalent Organic Framework-Based Light-Driven Microswimmers toward Therapeutic Applications.

ABSTRACT: While micromachines with tailored functionalities enable therapeutic applications in biological environments, their controlled motion and targeted drug delivery in biological media require sophisticated designs for practical applications. Covalent organic frameworks (COFs), a new generation of crystalline and nanoporous polymers, offer new perspectives for light-driven microswimmers in heterogeneous biological environments including intraocular fluids, thus setting the stage for biomedical applications such as retinal drug delivery. Two different types of COFs, uniformly spherical TABP-PDA-COF sub-micrometer particles and texturally nanoporous, micrometer-sized TpAzo-COF particles are described and compared as light-driven microrobots. They can be used as highly efficient visible-light-dri

SUBMITTER: Sridhar V 

PROVIDER: S-EPMC11475396 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature