Effectiveness of a fourth SARS-CoV-2 vaccine dose in previously infected individuals from Austria.

ABSTRACT:

Introduction

Evidence is limited on the effectiveness of a fourth vaccine dose against coronavirus disease 2019 (COVID-19) in populations with prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. We estimated the risk of COVID-19 deaths and SARS-CoV-2 infections according to vaccination status in previously infected individuals in Austria.

Methods

This is a nationwide retrospective observational study. We calculated age and gender adjusted Cox proportional hazard ratios (HRs) of COVID-19 deaths (primary outcome) and SARS-CoV-2 infections (secondary outcome) from 1 November to 31 December 2022, primarily comparing individuals with four versus three vaccine doses. Relative vaccine effectiveness (rVE) was calculated as (1-HR) X 100.

Results

Amon

SUBMITTER: Chalupka A 

PROVIDER: S-EPMC11475503 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature