Odd Chain Fatty Acids Are Not Robust Biomarkers for Dietary Intake of Fiber.

ABSTRACT:

Scope

Prior investigation has suggested a positive association between increased colonic propionate production and circulating odd-chain fatty acids (OCFAs; pentadecanoic acid [C15:0], heptadecanoic acid [C17:0]). As the major source of propionate in humans is the microbial fermentation of dietary fiber, OCFAs have been proposed as candidate biomarkers of dietary fiber. The objective of this study is to critically assess the plausibility, robustness, reliability, dose-response, time-response aspects of OCFAs as potential biomarkers of fermentable fibers in two independent studies using a validated analytical method.

Methods and results

OCFAs are first assessed in a fiber supplementation study, where 21 participants received 10 g dietary fiber supplementation for 7 days. OCFA

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11475553 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature