Tumor Immune Microenvironment Biomarkers for Recurrence Prediction in Locally Advanced Rectal Cancer Patients after Neoadjuvant Chemoradiotherapy.

ABSTRACT:

Background/objectives

The tumor microenvironment (TME) has emerged as a significant prognostic factor. This study aimed to identify prognostic factors by combining clinicopathologic parameters and the TME biomarkers in patients who underwent surgery following neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC).

Methods

CD8⁺ T cells, CXCR3, CXCL10, and α-smooth muscle actin (α-SMA) were analyzed via immunohistochemical staining. We also incorporated AI-powered digital pathology to assess the spatial TME. The associations between these biomarkers, clinicopathologic parameters, and survival outcomes were evaluated.

Results

CD8⁺ T cell expression, CXCR3 expression in tumor-infiltrating lymphocytes (TILs), and immune phenoty

SUBMITTER: Hwang JE 

PROVIDER: S-EPMC11475605 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature