Eosinophils respond to, but are not essential for control of an acute <i>Salmonella enterica</i> serovar Typhimurium infection in mice.

ABSTRACT: Eosinophils are a highly abundant cell type in the gastrointestinal tract during homeostatic conditions, where they have recently been reported to take on an activated phenotype following colonization by the bacterial microbiota. To date, there have been few studies investigating whether eosinophils respond to infection with enteric bacterial pathogens and/or investigating the requirements for eosinophils for effective bacterial pathogen control. In this study, we investigated the response of eosinophils to an acute enteric infection of mice with the bacterial pathogen Salmonella enterica serovar Typhimurium. We also assessed whether eosinophil deficiency impacted Salmonella burdens in the intestinal tract or impacted the systemic dissemination of Salmonella following

SUBMITTER: FitzPatrick RD 

PROVIDER: S-EPMC11475665 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature