The plasmid-encoded members of paralogous gene family 52 are dispensable to the enzootic cycle of <i>Borrelia burgdorferi</i>.

ABSTRACT: Lyme disease, the leading vector-borne disease in the United States and Europe, develops after infection with Borrelia burgdorferi sensu lato bacteria. Transmission of the spirochete from the tick vector to a vertebrate host requires global changes in gene expression that are controlled, in part, by the Rrp2/RpoN/RpoS alternative sigma factor cascade. Transcriptional studies defining the B. burgdorferi RpoS regulon have suggested that RpoS activates the transcription of paralogous family 52 (PFam52) genes. In strain B31, PFam52 genes (bbi42, bbk53, and bbq03) encode a set of conserved hypothetical proteins with >89% amino acid identity that are predicted to be surface-localized. Extensive homology among members of paralogous families complicates studies o

SUBMITTER: Groshong AM 

PROVIDER: S-EPMC11475691 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature