Physiological characteristics of neurons in the mammillary bodies align with topographical organization of subicular inputs.

ABSTRACT: The mammillary bodies (MBOs), a group of hypothalamic nuclei, play a pivotal role in memory formation and spatial navigation. They receive extensive inputs from the hippocampus through the fornix, but the physiological significance of these connections remains poorly understood. Damage to the MBOs is associated with various forms of anterograde amnesia. However, information about the physiological characteristics of the MBO is limited, primarily due to the limited number of studies that have directly monitored MBO activity along with population patterns of its upstream partners. Employing large-scale silicon probe recording in mice, we characterize MBO activity and its interaction with the subiculum across various brain states. We find that MBO cells are highly diverse in their relationshi

SUBMITTER: Nitzan N 

PROVIDER: S-EPMC11475818 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature