Germline Polymorphisms Associated with Overall Survival in Lung Adenocarcinoma: Genome-Wide Analysis.

ABSTRACT:

Background/objectives

Lung cancer remains a global health concern, with substantial variation in patient survival. Despite advances in detection and treatment, the genetic basis for the divergent outcomes is not understood. We investigated germline polymorphisms that modulate overall survival in 1464 surgically resected lung adenocarcinoma patients.

Methods

A multivariable Cox proportional hazard model was used to assess the association of more than seven million polymorphisms with overall survival at the 60-month follow-up, considering age, sex, pathological stage, decade of surgery and principal components as covariates. Genes in which variants were identified were studied in silico to investigate functional roles.

Results

Six germline variants passed the genome-wid

SUBMITTER: Minnai F 

PROVIDER: S-EPMC11475969 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature