An Exogenous Ketone Ester Slows Tumor Progression in Murine Breast and Renal Cancer Models.

ABSTRACT:

Background/objectives

Ketone esters (KEs) exhibit promise as anti-cancer agents but their impact on spontaneous metastases remains poorly understood. Although consumption of a ketogenic diet (KD) that is low in carbohydrates and high in fats can lead to KE production in vivo, the restrictive composition of KDs may diminish adherence in cancer patients.

Methods

We investigated the effects of an exogenous ketone ester-supplemented (eKET), carbohydrate-replete diet on tumor growth, metastasis, and underlying mechanisms in orthotopic models of metastatic breast (4T1-Luc) and renal (Renca-Luc) carcinomas. Mice were randomized to diet after tumor challenge.

Results

Administration of KEs did not alter tumor cell growth in vitro. However, in mice, our eKET diet increased circ

SUBMITTER: Ogbonna HN 

PROVIDER: S-EPMC11476193 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature