Dual-labeled anti-GD2 targeted probe for intraoperative molecular imaging of neuroblastoma.

ABSTRACT:

Background

Surgical resection is integral for the treatment of neuroblastoma, the most common extracranial solid malignancy in children. Safely locating and resecting primary tumor and remote deposits of disease remains a significant challenge, resulting in high rates of complications and incomplete surgery, worsening outcomes. Intraoperative molecular imaging (IMI) uses targeted radioactive or fluorescent tracers to identify and visualize tumors intraoperatively. GD2 was selected as an IMI target, as it is highly overexpressed in neuroblastoma and minimally expressed in normal tissue.

Methods

GD2 expression in neuroblastoma cell lines was measured by flow cytometry. DTPA and IRDye^® 800CW were conjugated to anti-GD2 antibody to generate DTPA-αGD2-IR800. Binding af

SUBMITTER: Rosenblum LT 

PROVIDER: S-EPMC11476241 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature