Pan-cancer analysis of Sp1 with a focus on immunomodulatory roles in gastric cancer.

ABSTRACT:

Background

Sp1, a transcription factor, regulates essential cellular processes and plays important tumorigenic roles across diverse cancers. However, comprehensive pan-cancer analyses of its expression and potential immunomodulatory roles remain unexplored.

Methods

Utilizing bioinformatics tools and public datasets, we examined the expression of Sp1 across normal tissues, tumors, and immune cells, and screened for pre- and post-transcriptional modifications, including genetic alterations, DNA methylation, and protein phosphorylation, affecting its expression or function. The association of Sp1 expression with immune cell infiltration, tumor mutational burden, and immune checkpoint signaling was also investigated. Single-cell transcriptome data was used to assess Sp1 expressi

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11476248 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature