Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction.

ABSTRACT:

Background

Members of the cellular communication network family (CCN) of matricellular proteins, like CCN1, have long been implicated in the regulation of cellular processes underlying wound healing, tissue fibrogenesis, and collagen dynamics. While many studies suggest antifibrotic actions for CCN1 in the adult heart through the promotion of myofibroblast senescence, they largely relied on exogenous supplementation strategies in in vivo models of cardiac injury where its expression is already induced-which may confound interpretation of its function in this process. The objective of this study was to interrogate the role of the endogenous protein on fibroblast function, collagen structural dynamics, and its associated impact on cardiac fibrosis after myocardial infarction (MI).

SUBMITTER: Fischer AG 

PROVIDER: S-EPMC11476287 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature