Oral Administration of <i>Lactiplantibacillus plantarum</i> CCFM8661 Alleviates Dichlorvos-Induced Toxicity in Mice.

ABSTRACT: Dichlorvos (DDVP) is an organophosphorus pesticide commonly used in agriculture for pest control, which may enter the organism from the food chain and cause harm. This study aimed to investigate the mitigation effect of Lactiplantibacillus plantarum CCFM8661 (a strain of the bacteria) on DDVP toxicity. Sixty male mice were randomly divided into five groups including control (saline), model (DDVP), low-dose, medium-dose, and high-dose groups, and alleviating effect was evaluated by determining body weight, pesticide residues, oxidative stress, and inflammation, and by histological analysis. The results showed that compared with the model group, body weight and acetylcholinesterase activity, and SOD, CAT, T-AOC, and GSH levels significantly increased, and serum DDVP content, MDA level

SUBMITTER: Ma W 

PROVIDER: S-EPMC11476327 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature