Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.

ABSTRACT: Glioblastoma (GBM) is a deadly brain cancer. The prognosis of GBM patients has marginally improved over the last three decades. The response of GBMs to initial treatment is inevitably followed by relapse. Thus, there is an urgent need to identify and develop new therapeutics to target this cancer and improve both patient outcomes and long-term survival. Metabolic reprogramming is considered one of the hallmarks of cancers. However, cell-based studies fail to accurately recapitulate the in vivo tumour microenvironment that influences metabolic signalling and rewiring. Against this backdrop, we conducted global, untargeted metabolomics analysis of the G7 and R24 GBM 2D monolayers and 3D spheroid cultures under identical cell culture conditions. Our studies revealed that the levels of multipl

SUBMITTER: Moosa NY 

PROVIDER: S-EPMC11476381 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature