Comparison and Determination of the Content of Mosapride Citrate by Different qNMR Methods.

ABSTRACT: As a salt-type compound, mosapride citrate's metabolism and side effects are correlated with its salt-forming ratio. Several techniques were developed in this work to compare various quantitative nuclear magnetic resonance (qNMR) methodologies and to quantitatively examine the content of raw materials. Among the qNMR techniques, methods for ¹H NMR and ¹⁹F NMR were developed. Appropriate solvents were chosen, and temperature, number of scans, acquisition time, and relaxation delay parameter settings were optimized. Maleic acid was chosen as the internal standard in ¹H NMR, and the respective characteristic signals of mosapride and citrate were selected as quantitative peaks. The internal standard in ¹⁹F NMR analysis was 4,4'-difluoro diphenylmetha

SUBMITTER: Lian X 

PROVIDER: S-EPMC11476420 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature