The Comparative Oncology of Canine Malignant Melanoma in Targeted Therapy: A Systematic Review of <i>In Vitro</i> Experiments and Animal Model Reports.

ABSTRACT: Canine malignant melanoma (CMM) is highly aggressive and mostly located in the oral cavity. CMM is the predominant type of canine oral malignancy and shows striking homologies with human mucosal melanoma. In comparative oncology, canine oral melanomas (COMs), as spontaneous tumor models, have the potential to acquire a unique value as a translational model of rare human melanoma subtypes. This review aims to provide a comprehensive summary of targeted therapies for canine malignant melanoma and to enrich the field of comparative oncology. Following the PRISMA guidelines, a comprehensive literature search was conducted across databases for studies from 1976 to April 2024. Studies were selected based on their relevance to targeted treatments. A total of 30 studies met the inclusion criteria.

SUBMITTER: He X 

PROVIDER: S-EPMC11476434 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature