The molecular anatomy of cashmere goat hair follicle during cytodifferentiation stage.

ABSTRACT:

Background

Cashmere, named as "soft gold", derives from the secondary hair follicles (SHFs) of cashmere goat which is vital to Northwest China's economy. The cytodifferentiation stage (E120), mirroring the complete hair follicle (HF) structure of adult goats and marking a critical phase in SHF development. Therefore, this study aims to enhance the understanding of SHF development and its impact on fiber quality, informing breeding strategies.

Results

From the scRNA-seq data analysis, the intricate processes and transcriptional dynamics of inner layer cell differentiation of HFs were unveiled in this study. we identified nine cell populations during cytodifferentiation and key structures such as the hair shaft and inner root sheath. And we discovered three main inner layer li

SUBMITTER: Li M 

PROVIDER: S-EPMC11476535 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature