Network efficiency of functional brain connectomes altered in type 2 diabetes patients with and without mild cognitive impairment.

ABSTRACT:

Aim

To explore the topological organization alterations of functional connectomes in type 2 diabetes (T2DM) patients with and without mild cognitive impairment (MCI), and compare these with structural connectomes changes.

Methods

Twenty-six T2DM patients with MCI (DM-MCI), 26 without cognitive impairment (DM-NC), and 28 healthy controls were included. Diffusion tensor imaging (DTI) and resting-state functional MRI images were acquired. Networks were constructed and graph-theory based network measurements were calculated. The global network parameters and nodal efficiencies were compared across the three groups using one-way ANOVA and a false-discovery rate correction was applied for multiple comparisons. Partial correlation analyses were performed to investigate relationship

SUBMITTER: Li J 

PROVIDER: S-EPMC11476597 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature