HIPI: Spatially resolved multiplexed protein expression inferred from H&E WSIs.

ABSTRACT: Solid tumors are characterized by complex interactions between the tumor, the immune system and the microenvironment. These interactions and intra-tumor variations have both diagnostic and prognostic significance and implications. However, quantifying the underlying processes in patient samples requires expensive and complicated molecular experiments. In contrast, H&E staining is typically performed as part of the routine standard process, and is very cheap. Here we present HIPI (H&E Image Interpretation and Protein Expression Inference) for predicting cell marker expression from tumor H&E images. We process paired H&E and CyCIF images taken from serial sections of colorectal cancers to train our model. We show that our model accurately predicts the spatial distribution of several importan

SUBMITTER: Zeira R 

PROVIDER: S-EPMC11476684 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature